Chemotherapy chemo is the use of anti-cancer drugs that are injected into a vein, under the skin, or into the cerebrospinal fluid CSF , or drugs that are taken by mouth to destroy or control cancer cells. Except when given into the CSF, these drugs enter the bloodstream and reach all areas of the body, making this treatment useful for cancers such as leukemia that spread throughout the body. Chemotherapy is the main treatment for most people with acute myeloid leukemia AML. Chemo is often not recommended for patients in poor health, but advanced age by itself is not a barrier to getting chemo. A third phase called maintenance or post-consolidation involves giving a low dose of chemo for months or years after consolidation is finished. If there are signs that the leukemia has reached the brain or spinal cord which is not common with AML , chemo might also be given into the CSF known as intrathecal chemo.
Phase II trial with oral idarubicin in advanced breast cancer
Anthracycline - Wikipedia
Clinical Drug Investigation. The toxicity of oral idarubicin has been examined in approximately patients with different forms of cancer. Myelosuppression neutropenia has been found to be quite acceptable at the doses required to have an antitumour effect, especially in breast cancer, lymphoma, and myelodysplasia. In acute myelogenous leukaemia, the therapy aims at achieving maximum myelosuppression; haematological and nonhaematological toxicities are difficult to compare in this clinical setting. Few serious septic events have been observed, with septic deaths being rarely reported.
Chemotherapy for Acute Myeloid Leukemia (AML)
Previous treatment with maximum cumulative dose of idarubicin or other anthracycline ; recent myocardial infarction ; severe arrhythmias ; severe myocardial insufficiency. Caution in handling—irritant to tissues. Caution is necessary with concurrent use of cardiotoxic drugs, or drugs that reduce cardiac contractility. Alopecia ; anaemia ; appetite decreased ; arrhythmias ; cardiomyopathy ; chills ; congestive heart failure ; diarrhoea ; embolism and thrombosis ; fever ; haemorrhage ; headache ; increased risk of infection ; leucopenia ; nausea ; neutropenia ; skin reactions ; stomatitis ; thrombocytopenia ; urine red ; vomiting.
Skip to search form Skip to main content. Of 37 evaluable patients, 4 In previously untreated patients the response rate was