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So, physicians treating people with red hair or a tendency to freckle, or whose parents did, have long been aware that something was up. Somatic mutations are changes to the underlying germline genes that exist only in the tumor sample and are therefore thought to play some role in cancer initiation or growth. Just 28 of the individuals whose tumors were genetically sequenced carried two of the R alleles linked to redheadedness. When they compared the somatic mutations in the tumors that came from these populations, researchers saw a clear pattern: Tumors taken from carriers of one or both R alleles, which researchers lumped together as a single group, had many more mutations than did those taken from melanoma patients who were not carriers at all. In carriers of the MC1R variants, even non-cancerous cells appeared to accumulate mutations more readily, the researchers found.